CHEMICAL TRANSFORMATIONS AND EVALUATION OF THE BASICITIES OF 4,5-DIHYDROPYRROLOBENZODIAZEPIN-6(7H)-ONES

Article abstract of DOI:10.1007/BF00506047

The alkaline hydrolysis, amidation, and methylation of 4,5-dihydropyrrolo<1,2,3-e,f><1,5>benzodiazepin-6(7H)-one derivatives under various conditions were investigated.The ionization constants (pK_α) for 1,2-dimethyl-4,5-dihydro<1,2,3-e,f,><1,5>benzodiazepin-6(7H)-one were calculated by the Hammett indicator method, and two values, viz. pK_α¹ = -2.37 and pK_α² = 5.53, which were ascribed to protonation of the diazepine ring and the indole ring of the molecule, respectively, were obtained.