Journal of Organic Chemistry p. 202 - 206 (1982)
Update date:2022-08-02
Topics:
Chavis, C.
Dumont, F.
Wightman, R. H.
Ziegler, J. C.
Imbach, J. L.
The synthesis of 2',3' asymmetrically substituted pyrimidine ribonucleosides in 70-95percent yields by using modified Vorbruggen conditions with "nonparticipating" 2-O-CH3 and 2-O-TBDMS ribofuranoses is described.Such compounds are useful synthons for oligoribonucleotide synthesis, including incorporation of "rare" bases.New and practically useful conditions for placement (using 1,2,4-triazole) and removal (KF/crown ether) of the tert-butyldimethylsilyl (TBDMS) protecting group are also reported.
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