Bioorganic and Medicinal Chemistry Letters p. 845 - 848 (1996)
Update date:2022-08-02
Topics:
Jew, Sang-Sup
Kim, Hee-Jin
Kim, Myoung Goo
Roh, Eun-Young
Cho, Youn-Sang
Kim, Joon-Kyum
Cha, Kyung-Hoe
Lee, Kang-Keun
Han, Hyun-Jung
Choi, Jae-Young
Lee, Heesoon
Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6c exhibited significant antitumor activity at wider range of doses as compared with camptothecin (T/C 243% at 70 mg/kg; T/C < 150% at 8.75-140 mg/kg).
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