Manipulating the diastereoselectivity of ortholithiation in planar chiral ferrocenes

Article abstract of DOI:10.1021/ol4013734

The sense of asymmetric ortholithiation directed by a chiral oxazoline may be inverted simply by the choice of achiral ligand. Comparison of results with a number of ferrocenyl oxazoline derivatives suggests that lithiation takes place by coordination to the oxazoline nitrogen irrespective of the ligand used.