Journal of Medicinal Chemistry p. 735 - 742 (1982)
Update date:2022-08-04
Topics:
Stokker, G. E.
Deana, A. A.
deSolms, S. J.
Schultz, E. M.
Smith, R. L.
et al.
A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack thereof, in a secon species.In general, substitution on nitrogen with groups other than lower alkyl or substitution on nitrogen and/or oxygen with groups resistant to hydrolysis substantially diminished or ablated saluretic effects.
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Doi:10.1016/S0040-4020(01)98892-1
(1981)Doi:10.1246/cl.1982.231
(1982)Doi:10.1007/BF00762029
(1982)Doi:10.1021/op060118l
(2006)Doi:10.1007/s10870-010-9951-z
(2011)Doi:10.1016/S0040-4039(01)83032-X
(1981)
