Effect of N,N'-Diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the 7,12-Dimethylbenzanthracene-Induced Mammary Carcinoma of the Rat

Article abstract of DOI:10.1021/jm00353a019

The syntheses and estrogen receptor affinities of meso- and (+/-)-N,N'-dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines (2) are described.They show high binding affinities in both diastereomeric forms but with a preference for the meso isomer