Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity

DOI: 10.1021/jm050257d

Source and publish data:

Journal of Medicinal Chemistry p. 7153 - 7165 (2005)

Update date:2022-08-05

Topics:

Authors:

Fattorusso, Caterina

Gemma, Sandra

Butini, Stefania

Huleatt, Paul

Catalanotti, Bruno

Persico, Marco

De Angelis, Meri

Fiorini, Isabella

Nacci, Vito

Ramunno, Anna

Rodriquez, Manuela

Greco, Giovanni

Novellino, Ettore

Bergamini, Alberto

Marini, Stefano

Coletta, Massimo

Maga, Giovanni

Spadari, Silvio

Campiani, Giuseppe

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Article abstract of DOI:10.1021/jm050257d

Pyrrolobenzoxazepinones (PBOs) represent a new class of human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) whose prototype is 5. Molecular modeling studies based on the X-ray structures of HIV-1 RT pro

Full text of DOI:10.1021/jm050257d

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