Total Synthesis of β-Santalol

Article abstract of DOI:10.1021/jo00160a009

A synthesis of β-santalol (2) is described by using camphenesultone (4) as the starting material.Alkylation of the sultone 4 with the tetrahydropyranyl ether of 2-bromoethanol (11) followed by reaction with phenyllithium and desulfurization with sodium amalgam produced the monoprotected diol 16.The intermediate 1 was converted to bicycloekasantalal which has been previously transformed into β-santalol (2).