SYNTHESIS OF (+)-2R,3R,11R,12R- AND (-)-2S,3S,11S,12S-TETRAPHENYL-18-CROWN-6

Article abstract of DOI:10.1016/S0040-4039(00)85812-8

The synthesis of the title crown ethers starting from optically active hydrobenzoins is described.R(+)-1, in CDCl3, preferentially extracts R(+)-phenylglycine methyl ester hydroperchlorate from an aqueous solution of the racemate with a chiral recognition factor of 1.5 as shown by nmr measurements.