Journal of Medicinal Chemistry p. 5419 - 5422 (2005)
Update date:2022-08-03
Topics:
Jaye, Michael C.
Krawiec, John A.
Campobasso, Nino
Smallwood, Angela
Qiu, Chunyan
Lu, Quinn
Kerrigan, John J.
De Los Frailes Alvaro, Maite
Laffitte, Bryan
Liu, Wu-Schyong
Marino Jr., Joseph P.
Meyer, Craig R.
Nichols, Jason A.
Parks, Derek J.
Perez, Paloma
Sarov-Blat, Lea
Seepersaud, Sheila D.
Steplewski, Klaudia M.
Thompson, Scott K.
Wang, Ping
Watson, Mike A.
Webb, Christine L.
Haigh, David
Caravella, Justin A.
Macphee, Colin H.
Willson, Timothy M.
Collins, Jon L.
Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression. Mechanism of action studies led to the identification of GSK3987 (4) as an LXR ligand. 4 r
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