Bulletin of the Chemical Society of Japan p. 1116 - 1119 (1983)
Update date:2022-08-03
Topics:
Otagiri, Ken
Miyake, Ichizo
Ishibashi, Norio
Fukui, Hiroshi
Kanehisa, Hidenori
Okai, Hideo
In order to investigate the relationship between bitterness and chemical structure of BPIa, eleven kinds of fragments and analogs of BPIa were synthesized. des-Gly2-BPIa and des-Pro4-BPIa exhibited extremely bitter taste. However, the pentapeptide (Arg-Gly-Pro-Pro-Phe) of BPIa possessed weak bitterness. The bitterness exhibition of BPIa probably derived from the spatial structure of its molecule.
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