ACETALS OF LACTAMS AND ACID AMIDES. 38. SYNTHESIS OF PYRIMIDINE AND PYRIDINE DERIVATIVES ON THE BASIS OF THE REACTION OF ENAMINO AMIDES WITH AMIDE ACETALS

Article abstract of DOI:10.1007/BF00523081

Derivatives of 1-benzyl-4-pyrimidinones and 1-benzyl-6-pyrimidinones were synthesized by the reaction of α-cyano-β-N-benzylaminocrotonamide and α-cyano-β-aminocrotonic acid N-benzylamine with dimethylformamide diethylacetal.When 1-benzyl-5-cyano-6-(β-dimethylamino)vinyl-1,6-dihydro-4-pyrimidinone is heated in an alkaline medium, it is converted to 3-cyano-4-benzylamino-2-pyridone, from which a pyrido<1,2-a>pyrimidine derivative was synthesized.When 1-benzyl-5-cyano-4-(β-dimethylamino)vinyl-1,6-dihydro-6-pyrimidinone is heated in alkaline solution, it is converted to α-cyano-β-hydroxycrotonic acid N-benzylamide.