Stereocontrolled Synthesis of the Spiro Ketal Unit of Avermectin B1a Aglycon

Article abstract of DOI:10.1021/jo00171a065

A stereocontrolled total synthesis of the 1,7-dioxaspiro<5.5>undecene subunit of the avermectin B^1a aglycon is presented based on the "chiron" approach which utilizes optically active starting materials.