Optimisation of a novel series of selective CNS penetrant CB2 agonists

DOI: 10.1016/j.bmcl.2011.05.063

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4284 - 4287 (2011)

Update date:2022-07-29

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Authors:

Watson, Christine

Owen, Dafydd R.

Harding, Denise

Kon-I, Kana

Lewis, Mark L.

Mason, Helen J.

Matsumizu, Miyako

Mukaiyama, Takasuke

Rodriguez-Lens, Margarita

Shima, Akiko

Takeuchi, Mifune

Tran, Isabelle

Young, Tim

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Article abstract of DOI:10.1016/j.bmcl.2011.05.063

A series of benzimidazole CB₂ receptor agonists were prepared and their properties investigated. Optimisation of the three benzimidazole substituents led to the identification of compound 23, a potent CB₂ full agonist (EC_{50
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Full text of DOI:10.1016/j.bmcl.2011.05.063

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