Methotrexate Analogues. 19. Replacement of the Glutamate Side Chain in Classical Antifolates by L-Homocysteic Acid and L-Cysteic Acid: Effect on Enzyme Inhibition and Antitumor Activity

DOI: 10.1021/jm00371a008

Source and publish data:

Journal of Medicinal Chemistry p. 600 - 604 (1984)

Update date:2022-08-04

Topics:

Authors:

Rosowsky, Andre

Forsch, Ronald A.

Freisheim, James H.

Moran, Richard G.

Wick, Michael

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00371a008

Methotrexate (MTX) and aminopterin (AMT) analogues containing L-homocysteic acid or L-cysteic acid in place of L-glutamic acid were synthesized and tested as inhibitors of dihydrofolate reductase from L1210 cells and folyl polyglutamate synthetase from mo

Full text of DOI:10.1021/jm00371a008

Products guided by the article

Product name:L-Alanine, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-3-sulfo-

Cas No:89043-72-1

R&D Labs maybe for 89043-72-1

HAORUI ENTERPRISES LLC

Contact:(1) 206-3550089

Address:5115 NE 8TH PL, Renton, WA 98059 USA
Luoyang Aoda chemical Co.,Ltd.

Contact:+86-379-67518785 67516588

Address:MiaoWan industry district,YanShi City,Henan,China
Shandong Bolode Bio-Technology Co., LTD

Contact:+86-0531-58966870

Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China
Cerametek Materials（ShenZhen）Co., Ltd.

Contact:+86-755-2324.2554

Address:A3-#9, YongChuan Street, Suite 501
Lian Xing Chemical Co.,Ltd.

Contact:0792-8228321

Address:10TH Floor No.121 binjiang Road Xunyang District

Relevant to this article

Synthesis of a novel ditopic ligand incorporating directly bonded 1,10-phenanthroline and 2,2′:6′,2″-terpyridine units

Doi:10.1016/j.tetlet.2006.03.025
(2006)
An improved synthetic route to angularly functionalized hydrofluorene derivatives through Pd(0)-catalyzed heck reaction

Doi:10.1055/s-2006-926408
(2006)
Photoinduced Sulfur-Nitrogen Bond Rotation and Thermal Nitrogen Inversion in Heterocumulene OSNSO

Doi:10.1021/jacs.7b12622
(2018)
Anthracyclines. XI. A short, site-specific synthesis of unsymmetrical 3-acetyl-5,8-dialkoxy-1,2-dihydronaphthalenes; key precursors to daunomycinone AB-synthons

Doi:10.1071/CH9841721
(1984)
Doi:10.1016/S0020-1693(00)84414-X
(1986)
Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Doi:10.1016/j.bmcl.2007.12.035
(2008)

Article Doi