Methotrexate Analogues. 19. Replacement of the Glutamate Side Chain in Classical Antifolates by L-Homocysteic Acid and L-Cysteic Acid: Effect on Enzyme Inhibition and Antitumor Activity

DOI: 10.1021/jm00371a008

Source and publish data:

Journal of Medicinal Chemistry p. 600 - 604 (1984)

Update date:2022-08-04

Topics:

Authors:

Rosowsky, Andre

Forsch, Ronald A.

Freisheim, James H.

Moran, Richard G.

Wick, Michael

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Article abstract of DOI:10.1021/jm00371a008

Methotrexate (MTX) and aminopterin (AMT) analogues containing L-homocysteic acid or L-cysteic acid in place of L-glutamic acid were synthesized and tested as inhibitors of dihydrofolate reductase from L1210 cells and folyl polyglutamate synthetase from mo

Full text of DOI:10.1021/jm00371a008

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