Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

DOI: 10.1021/jm00068a011

Source and publish data:

Journal of Medicinal Chemistry p. 2343 - 2349 (1993)

Update date:2022-08-05

Topics:

Authors:

Kubo Kubo

Kohara Kohara

Yoshimura

Inada Inada

Shibouta

Furukawa

Kato Kato

Nishikawa

Naka Naka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00068a011

In order to improve the oral bioavailability (BA) of 2-butyl-1-[[2'-(1H- tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (3: CV-11194) and 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylic acid (

Full text of DOI:10.1021/jm00068a011

Products guided by the article

Product name:N-Trityl Candesartan

Cas No:894806-43-0

R&D Labs maybe for 894806-43-0

Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands
SHIFANG SUHONG CHEMICAL CO.,LTD

Contact:+86-838-2224563

Address:Room 1207 Zongchen Sunshine No.128 Taishan South Road,Deyang City,Sichuan China
Xiamen Kaijia Imp & Exp Co., Ltd.

Contact:86-592-5101177

Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
Shanghai Haoyuan Chemexpress Co., Ltd.

website:https://www.chemexpress.com/

Contact:86-21-58950125

Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
Santow Laboratory Limited

Contact:+86-371-55981030

Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan

Relevant to this article

Doi:10.1002/hlca.19490320319
(1949)
The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite

Doi:10.1021/jm00373a008
(1984)
Optimization of 2-acylaminocycloalkylthiophene derivatives for activity against Staphylococcus aureus RnpA

Doi:10.3390/antibiotics10040369
(2021)
Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors

Doi:10.1016/j.bmc.2018.02.022
(2018)
Reactivity of cyclic sulfamidates towards sulfur-stabilised enolates. Stereocontrolled synthesis of functionalised lactams

Doi:10.1039/b601804a
(2006)
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions

Doi:10.1021/jm060011o
(2006)

Article Doi