Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

DOI: 10.1021/jm00068a011

Source and publish data:

Journal of Medicinal Chemistry p. 2343 - 2349 (1993)

Update date:2022-08-05

Topics:

Authors:

Kubo Kubo

Kohara Kohara

Yoshimura

Inada Inada

Shibouta

Furukawa

Kato Kato

Nishikawa

Naka Naka

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Article abstract of DOI:10.1021/jm00068a011

In order to improve the oral bioavailability (BA) of 2-butyl-1-[[2'-(1H- tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (3: CV-11194) and 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylic acid (

Full text of DOI:10.1021/jm00068a011

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