Chemoselective Acylation of Primary Amines in the Presence of Secondary Amines with Acyl Cyanides. Highly Efficient Methods for the Synthesis of Spermidine and Spermine Alkaloid

DOI: 10.1246/cl.1987.879

Source and publish data:

Chemistry Letters p. 879 - 882 (1987)

Update date:2022-07-31

Topics:

Authors:

Murahashi, Shun-Ichi

Naota, Takeshi

Nakajima, Nobuyuki

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Article abstract of DOI:10.1246/cl.1987.879

Acyl cyanides are highly useful reagents for the chemoselective acylation of primary amines in the presence of secondary amines.The reaction provides the versatile method for the shortstep synthesis of various naturally occurring polyamines.

Full text of DOI:10.1246/cl.1987.879

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