A new approach to oligonucleotide N3′-→P5′ phosphoramidate building blocks

Article abstract of DOI:10.1081/NCN-200060068

A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxy nucleosides as the key starting materials. The final phosphoramidite products were obtained with high yields via 2-3-step efficient chemical transformations using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties. Copyright Taylor & Francis, Inc.