Nucleosides, nucleotides and nucleic acids p. 1063 - 1067 (2005)
Update date:2022-08-05
Topics:
Zielinska, Daria
Pongracz, Krisztina
Gryaznov, Sergei
A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxy nucleosides as the key starting materials. The final phosphoramidite products were obtained with high yields via 2-3-step efficient chemical transformations using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties. Copyright Taylor & Francis, Inc.
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