Heterocyclic Communications p. 485 - 490 (2005)
Update date:2022-08-04
Topics:
Satyanarayana, Bollikonda
Sumalatha, Yasareni
Kumar, Sythana Suresh
Venkatraman, Sundaram
Reddy, Ghanta Mahesh
Reddy, Padi Pratap
Aripiprazole is a recently developed anti-psychotic drug used for the treatment of schizophrenia. Aripiprazole and its N-oxides exhibit a strong activity for influencing the neurotransmission of dopamine receptors and are devoid of side effects induced by the known drugs useful for the treatment of schizophrenia. Further, Aripiprazole is metabolized by different biotransformation pathways as dehydrogenation, hydroxylation and N-dealkylation giving rise to different metabolites. The present work details the development of a simple and novel process for the preparation of Aripiprazole N-oxides as Aripiprazole-4-N-oxide, Aripiprazole-1-N-oxide and Aripiprazole-1,4-di-N-oxide and Aripiprazole metabolites such as dehydro Aripiprazole and Aripiprazole hydroxy metabolite.
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