An efficient synthesis of (+)-Anatoxin-a.

Article abstract of DOI:10.1016/S0957-4166(00)82084-4

An efficient synthesis (38 percent overall yield in 8 steps starting from 2) of the potent neurotoxin (+)-anatoxin-a is described.The key step involves the stereoselective addition of 5-hexenylcopper to the chiral N-acyliminium ion 2a.