Synthesis and structural characterisation as 12-helix of the hexamer of a β-amino acid tethered to a pyrrolidin-2-one ring

Article abstract of DOI:10.1039/b612071g

Starting from (3S,4R,1′S)-3-amino-2-oxo-1-[1′-(4- methoxyphenylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a β-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirme