
Journal of Organic Chemistry p. 4332 - 4339 (1984)
Update date:2022-08-04
Topics: Synthesis Yield Catalyst Isolation Inhibitor Purification Natural product Reactant Protein synthesis
Roush, William R.
Blizzard, Timothy A.
A four-step synthesis of verrucarin B (3) from verrucarol (2) is described.Coupling of 2 with in situ generated carboxylic acid 5 proceeded with moderate regioselectivity and afforded trichothecene monoester 14 in only 35 percent yield.It was necessary th
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