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4a: Yield: 76.46%, m.p. 140-150 °C, Anal. Calc. for C31H23N2O3Cl: C, 73.44; H, 4.57;
N, 5.53%; Found: C, 73.41; H, 4.59; N, 5.49%. IR (KBr): 748.245 (C-Cl bending), 1299.79
(C-N), 1641.13 (C=O), 1689.34 (C=O stretching β-lactam) and 1719.23 cm-1 (aromatic C=C
stretching).
4b: Yield: 78.99%, m.p. 174-176 °C, Anal. Calc. for C31H22N2O3Cl2: C, 68.77; H, 4.10; N,
5.17%; Found: C, 68.72; H, 4.13; N, 5.19%. IR (KBr): 783.922 (C-Cl bending), 1281.47
(C-N), 1646.91 (C=O), 1677.77 (aromatic C=C stretching), 1700.91 (C=O stretching β-lactam)
and 3349.75 cm-1 (O-H stretching); 1H NMR: δ 2.436 (s,3H,CH3); 4.282 (s,1H,Ar-OH); 4.937
(s,1H,CH-N of β- lactam); 6.817 (d,1H,C-C6H5 of β- lactam) and 8.708-7.331 ppm
(m,15H,Ar-H); and MS: m/z 545.3 (17.72%), 542.9 (43.03%), 535.3 (M+, 100% base peak),
529.3 (43.03%), 523.1 (56.96%), 521.3 (74.68%), 508.7 (55.69%) and 507.4 (68.35%).
4c: Yield: 76.72%, m.p. 168-170 °C, Anal. Calc. for C31H22N3O5Cl: C, 67.46; H, 4.02;
N, 7.61%; Found: C, 67.44; H, 4.05; N, 7.59%. IR (KBr): 789.707 (C-Cl bending), 1348
(C-N), 1521.56 (N=O stretching), 1659.45 (C=O), 1689.34 (C=O stretching β-lactam),
1737.55 (aromatic C=C stretching), 3140.51 (aromatic C-H stretching) and 3218.61 cm-1 (O-
H stretching).
4d: Yield: 75%, m.p. 100-104 °C, Anal. Calc. for C33H28N3O3Cl: C, 72.06; H, 5.13; N,
7.64%; Found: C, 72.09; H, 5.14; N, 7.63%. IR (KBr): 783.922 (C-Cl bending), 1275.68
(C-N), 1611.23 (aromatic C=C stretching), 1646.91 (C=O), 1671.02 (C=O stretching
β-lactam) and 2978.52 cm-1 (aromatic C-H stretching).
4e: Yield: 72.36%, m.p. 148-150 °C, Anal. Calc. for C34H29N2O6Cl: C, 68.40; H, 4.90;
N, 4.69%; Found: C, 68.38; H, 4.92; N, 4.72%. IR (KBr): 765.601 (C-Cl bending), 1245.79
(Ph-O-C stretching), 1359.57 (C-N), 1641.13 (C=O), 1671.02 (C=O stretching β-lactam)
and 3373.85 cm-1 (O-H stretching).
4f: Yield: 78.35%, m.p. 112-115 °C, Anal. Calc. for C32H25N2O4Cl: C, 71.57; H, 4.69;
N, 5.22%; Found: C, 71.55; H, 4.67; N, 5.27%. IR (KBr): 782.958 (C-Cl bending), 1143.58
(C-N), 1244.83 (Ph-O-C stretching), 1641.13 (C=O), 1676.8 (C=O stretching β-lactam),
2878.24 (aromatic C-H stretching) and 3375.78 cm-1 (O-H stretching).
4g: Yield: 74.23%, m.p. 141-145 °C, Anal. Calc. for C31H23N2O4Cl: C, 71.20; H, 4.43;
N, 5.36%; Found: C, 71.18; H, 4.44; N, 5.32%. IR (KBr): 771.387 (C-Cl bending), 1280.5
(C-N), 1676.8 (C=O stretching β-lactam), 1641.13 (C=O) and 3375.78 cm-1 (O-H
stretching).
4h: Yield: 68.26%, m.p. 139-142 °C, Anal. Calc. for C31H22N3O5Cl: C, 67.46; H, 4.02;
N, 7.61%; Found: C, 67.48; H, 4.05; N, 7.59%. IR (KBr): 788.743 (C-Cl bending), 1267.97
(C-N), 1558.2 (N=O stretching), 1646.91 (C=O), 1682.59 (C=O stretching β-lactam) and
3162.69 cm-1 (O-H stretching).
4i: Yield: 59.39%, m.p. 138-140 °C, Anal. Calc. for C31H23N2O4Cl: C, 71.20; H, 4.43;
N, 5.36%; Found: C, 71.23; H, 4.45; N, 5.38%. IR (KBr): 756.601 (C-Cl bending), 1280.5
(C-N), 1611.23 (aromatic C=C stretching), 1646.91 (C=O), 1671.02 (C=O stretching
β-lactam) and 3381.57 cm-1 (O-H stretching).
4j: Yield: 77.96%, m.p. 150-155 °C, Anal. Calc. for C29H21N2O4Cl: C, 70.09; H, 4.26;
N, 5.64%; Found: C, 70.06; H, 4.28; N, 5.66%. IR (KBr): 765.601 (C-Cl bending), 1065.48
(C-O), 1371.14 (C-N), 1641.13 (C=O) and 1677.77 cm-1 (C=O stretching β-lactam).
Anticonvulsant activity
The experimental protocol was approved by the Institutional Animal Ethical Committee
(IAEC) and was conducted according to the guidelines for use and care of experimental