Bioorganic and Medicinal Chemistry Letters p. 2851 - 2854 (2010)
Update date:2022-08-02
Topics:
Sandanayaka, Vincent
Mamat, Bjorn
Bhagat, Nikhil
Bedell, Louis
Halldorsdottir, Gudrun
Sigthorsdottir, Heida
Andrésson, Thorkell
Kiselyov, Alex
Gurney, Mark
Singh, Jasbir
Novel piperidine and piperazine derivatives have been designed and tested as inhibitors of LTA4 hydrolase (LTA4H). Most potent compounds showed good potency in both enzymatic and functional human whole blood assay. Crystallography studies further confirmed observed structure-activity relationship and LTA4H binding mode for analogs from the piperidine series.
View MoreShanghai Yuanye Bio-Technology Co., Ltd.
website:http://www.shyuanye.com
Contact:+86-21-61845781
Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Melone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd
Contact:86-27-52341789
Address:Room 1518 B suite, optical valley time square, No 111 Guanshan Road, Hongshan District,Wuhan,Hubei Province,China.
Shenzhen Feiming Science and Technology Co,. Ltd
Contact:+86-755-85232577
Address:#B2309, Fenglin International Center ,Jixiang Road, Longcheng street, LongGang District, Shenzhen city, Guangdong province, China.
Yantai Derun Liquid Crystal Materials Co. Ltd.
website:http://www.ytderun.com
Contact:86-535-6300169
Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI
Doi:10.1021/jm200884j
(2011)Doi:10.1039/c2tb00420h
(2013)Doi:10.1007/BF02439259
()Doi:10.1021/jo00253a045
(1988)Doi:10.1021/ol048802c
(2004)Doi:10.1016/0040-4039(95)00106-M
(1995)