Helvetica Chimica Acta p. 1356 - 1364 (1984)
Update date:2022-08-02
Topics:
Chollet, Andre
Ayala, Edgar
Kawashima, Eric H.
The synthesis of oligodeoxyribonucleotides on a cross-linked polystyrene solid support utilizing stable mono- and dinucleotide phosphotriester building blocks is presented.The use of O6-<2-(p-nitrophenyl)ethyl>-2'deoxyguanosine derivatives yields cleaner DNA fragments by supressing side reactions.Modifications improving the phosphotriester methodology are presented.The purification methods and analysis of synthetic oligodeoxyribonucleotides are described.
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(2013)Doi:10.1016/j.jorganchem.2006.11.016
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(2006)
