Improved Synthesis of Oligodeoxyribonucleotides by Solid-Phase Phosphotriester Method Utilizing O6--2'-deoxyguanosine Derivatives

DOI: 10.1002/hlca.19840670521

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Helvetica Chimica Acta p. 1356 - 1364 (1984)

Update date:2022-08-02

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Authors:

Chollet, Andre

Ayala, Edgar

Kawashima, Eric H.

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Article abstract of DOI:10.1002/hlca.19840670521

The synthesis of oligodeoxyribonucleotides on a cross-linked polystyrene solid support utilizing stable mono- and dinucleotide phosphotriester building blocks is presented.The use of O⁶-<2-(p-nitrophenyl)ethyl>-2'deoxyguanosine derivatives yields cleaner DNA fragments by supressing side reactions.Modifications improving the phosphotriester methodology are presented.The purification methods and analysis of synthetic oligodeoxyribonucleotides are described.

Full text of DOI:10.1002/hlca.19840670521

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