Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors

DOI: 10.1016/j.bmcl.2007.04.052

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3575 - 3580 (2007)

Update date:2022-08-03

Topics:

Authors:

Holsworth, Daniel D.

Jalaie, Mehran

Belliotti, Thomas

Cai, Cuiman

Collard, Wendy

Ferreira, Suzie

Powell, Noel A.

Stier, Michael

Zhang, Erli

McConnell, Pat

Mochalkin, Igor

Ryan, Michael J.

Bryant, John

Li, Tingsheng

Kasani, Aparna

Subedi, Rajendra

Maiti, Samarendra N.

Edmunds, Jeremy J.

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Article abstract of DOI:10.1016/j.bmcl.2007.04.052

Novel 2,4-diaminopyrimidine-based small molecule renin inhibitors are disclosed. Through high throughput screening, parallel synthesis, X-ray crystallography, and structure based drug design, we have developed the first non-chiral, non-peptidic, small mol

Full text of DOI:10.1016/j.bmcl.2007.04.052

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