First asymmetric synthesis of a C2-symmetric 2-endo,6-endo-disubstituted bispidine

Article abstract of DOI:10.1016/j.tetasy.2007.06.010

The enantioselective synthesis of a C₂-symmetric 2-endo,6-endo-disubstituted bispidine (3,7-diazabicyclo[3.3.1]nonane) has been accomplished for the first time. The key step was a Michael addition of the protected β-amino ester methyl (R)-3-{N-