SEQUENTIAL DIRECTED ORTHO METALATION REACTIONS. A SYNTHESIS OF ANTHRAMYCIN.

DOI: 10.1016/S0040-4039(01)81611-7

Source and publish data:

Tetrahedron Letters p. 5505 - 5508 (1984)

Update date:2022-08-04

Topics:

Authors:

Reed, N. J.

Snieckus, V.

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Article abstract of DOI:10.1016/S0040-4039(01)81611-7

The pyrrolo<1,4>benzodiazepine 2 , a key intermediate in the synthesis of anthramycin (1), has been prepared via a new approach involving two sequential directed ortho metalation reactions (4) and a previously unreported isatoic anhydride construction (8(*) 9).

Full text of DOI:10.1016/S0040-4039(01)81611-7

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