Very Selective Enzymatic Hydrolysis of α-Ester of Dimethyl α-Dehydroglutamate with Papain

DOI: 10.1246/cl.1988.2001

Source and publish data:

Chemistry Letters p. 2001 - 2002 (1988)

Update date:2022-08-05

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Authors:

Shin, Chung-gi

Takahashi, Nobuyuki

Yonezawa, Yasuchika

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Article abstract of DOI:10.1246/cl.1988.2001

It was found that the selective ester hydrolysis of N-benzyloxycarbonyl-α-dehydroglutamic acid dimethyl ester with papain at pH 8.0 was achieved readily to give only a Cbz-ΔGlu(OMe)-OH almost quantitatively.

Full text of DOI:10.1246/cl.1988.2001

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