Very Selective Enzymatic Hydrolysis of α-Ester of Dimethyl α-Dehydroglutamate with Papain

Article abstract of DOI:10.1246/cl.1988.2001

It was found that the selective ester hydrolysis of N-benzyloxycarbonyl-α-dehydroglutamic acid dimethyl ester with papain at pH 8.0 was achieved readily to give only a Cbz-ΔGlu(OMe)-OH almost quantitatively.