Journal of Organic Chemistry p. 3481 - 3484 (1985)
Update date:2022-08-05
Topics:
Nordlander, J. Eric
Njoroge, F. George
Payne, Mark J.
Warman, Dhiraj
Chiral N-(trifluoroacetyl)-α-amino acid chlorides unergo Friedel-Crafts reaction with benzene and 1,2-dimethoxybenzene under mild conditions commonly with complete (>99percent) preservation of configurational identity.The resultant (trifluoroacetyl)amino ketones may be deoxygenated with Et3SiH or H2/Pd-C in acidic media to the corresponding N-(trifluoroacetyl)-β-arylalkylamines likewise without loss of configurational purity.
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