Magnetic Resonance in Chemistry p. 295 - 298 (1989)
Update date:2022-08-03
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Botlan, D. J. Le
It has previously been shown the formaldehyde causes the formation of hydroxymethylated derivatives with nucelobases, buth these were identified after separationn of reaction products; such handling might destroy labile derivatives or remove products present in small proportions.This work is based on a study of the reactivity of formaldehyde on adenine, adenosine and adenosine monophosphate in the reaction medium.It demonstrates the high reactivity of the N-9 site of adenine, the reactivity of the hydroxymethyl at the C-5' of the ribose and brings to light such new derivatives as N-9-CH2OCH2OH and N-6-CH2OCH2OH.Further, the order of appearence of different derivetives and their approximate determination were achieved. KEY WORDS Formaldehyde Adenine Adenosine Adenosine monophosphate
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