Stereocontrolled Syntheses for the Six Diastereomeric 1,2-Dihydroxy-4,5-diaminocyclohexanes: PtII Complexes and P-388 Antitumor Properties

DOI: 10.1021/jm00391a011

Source and publish data:

Journal of Medicinal Chemistry p. 1327 - 1336 (1987)

Update date:2022-08-02

Topics:

Authors:

Witiak, Donald T.

Rotella, David P.

Filppi, Joyce A.

Gallucci, Judith

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Article abstract of DOI:10.1021/jm00391a011

Stereocontrolled syntheses for the six diastereomeric 1,2-dihydroxy-4,5-diaminocyclohexanes 3a-f from cyclohexene diamines cis-4 and trans-5 are described.Cbz-protected species cis-9 and trans-11, respectively, served as a source of stable Cbz-protected p

Full text of DOI:10.1021/jm00391a011

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