Defined Dimensional Alterations in Enzyme Substrates. General Synthetic Methodology for the Bent Dihydro-lin-benzopurines

Article abstract of DOI:10.1021/jo00355a009

The use of cycloaddition reactions for the synthesis of partially reduced heterocyclic systems has been shown to be an attractive approach to dihydrobenzimidazoles, dihydroquinazolines, and dihydro-lin-benzopurines.The first representatives of the bent dihydro-lin-benzopurines to be synthesized were 4,9-dihydroimidazo<4,5-g>-quinazoline-2,8-(1H,7H)-dione (20) and 4,9-dihydro-lin-benzouric acid (21).