Platinum-catalysed enantioselective hydroformylation of styrene. Platinum-diphosphine-tin(II)fluoride catalytic system: a novel asymmetric hydroformylation catalyst

Article abstract of DOI:10.1016/0022-328X(93)80341-8

Enantioselective hydroformylation of styrene was carried out in the presence of platinum-containing catalysts.Tin(II) fluoride was used as cocatalyst, giving a catalytic system of unusually high stability.When the optically active diphosphine 2,4-bis(diphenylphosphino)pentane (BDPP) was used the absolute configuration of the 2-phenylpropanol formed varied with the temperature used.In dichloromethane the enantiomeric excess depends strongly on the temperature used.Although the addition of 2-diphenylphosphino-pyridine to the catalytic system strongly reduces the catalytic activity, the BDPP-2-diphenylphosphino-pyridine "mixed-phosphine system" gave 86.7percent e.e.