Journal of Organic Chemistry p. 5886 - 5894 (2016)
Update date:2022-08-17
Topics:
Aithagani, Sravan Kumar
Kumar, Mukesh
Yadav, Mahipal
Vishwakarma, Ram A.
Singh, Parvinder Pal
Herein, we report a simple and metal-free method for the synthesis of N-azine sulfoximines by the nucleophilic substitution of azine N-oxides with NH-sulfoximines. The present method works at room temperature with wide functional group compatibility and gives several unprecedented N-azine sulfoximines. The reaction conditions were also found suitable with enantiopure substrates and furnished products without any racemization. It also finds an application in the sulfoximination of azine-based functional molecules such as 2,2′-bipyridine, 1,10-phenanthroline, and quinine.
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