Highly diastereoselective alkylation of a pyroglutamate derivative with an electrophile obtained from indole. Synthesis of a potential intermediate for the preparation of the natural sweetener (-)-Monatin

Article abstract of DOI:10.1080/00397910008087393

The synthesis of a potential intermediate for the preparation of the very intensive sweetening agent (-)-Monatin is described. The synthesis is based on a highly diastereoselective alkylation reaction of a pyroglutamate derivative with an electrophile obtained from indole.

Full text of DOI:10.1080/00397910008087393

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Synthetic Communications: An
International Journal for Rapid
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Highly Diastereoselective
Alkylation of a Pyroglutamate
Derivative with an Electrophile
Obtained from Indole.
Synthesis of a Potential
Intermediate for the
Preparation of the Natural
Sweetener (-)-Monatin
a
a
Davi de Jesus Oliveira & Femando Coelho
a
Instituto de Quimica – UNICAMP , PO Box 6154 –-
3083–970, Campinas, SP, Brazil
1
Published online: 04 Dec 2007.
To cite this article: Davi de Jesus Oliveira & Femando Coelho (2000) Highly
Diastereoselective Alkylation of a Pyroglutamate Derivative with an Electrophile
Obtained from Indole. Synthesis of a Potential Intermediate for the Preparation of the
Natural Sweetener (-)-Monatin, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 30:12, 2143-2159, DOI:
10.1080/00397910008087393
To link to this article: http://dx.doi.org/10.1080/00397910008087393
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