Chemistry of Heterocyclic Compounds p. 1358 - 1364 (1991)
Update date:2022-08-30
Topics:
Trushule, M.
Kupche, E.
Augustane, I.
Verovskii, N. V.
Lukevits, E.
et al.
1-(Tetrahydrofuryl) derivatives of 5-trimethylgermyl(silyl)uracil and uracil derivatives of 3-(5-nitro-2-furyl)acrylic acid, as well as 1-(γ-triethylgermyl)- and 1-(γ-triethoxysilyl)propylcarbamoyl-5-fluorouracils, were synthesized.Six of the 14 new investigated compounds have high cytotoxic activity in a culture of melanoma B16 cells. 5-Fluorouracil derivatives of 3-(5-nitro-2-furyl)acrylic acid display antitumorigenic activity with respect to lympholeucosis P388 that is comparable to the activity of ftorafur.It was demonstrated by electrochemical studies that the antitumorigenic activity is not determined by the redox properties of the investigated compounds.
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