A nickelacycle as propionic acid equivalent for carbon-carbon coupling reactions; application to the synthesis of C25 steroid carboxylic acids

Article abstract of DOI:10.1016/S0040-4039(00)88779-1

β-Substituted propionic acids are prepared in good yields by carbon-carbon coupling reaction of the nickelacycle 1 with organic iodides and anhydrous manganese(II) iodide. This new reaction is used to the synthesis of C₂₅ steroid carboxylic acids from C₂₂ steroid iodides.