Direct synthesis, substitution, and structure of 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-4-pentafluorophenylpyrimidin- 2H-one

Article abstract of DOI:10.1016/0040-4039(95)00587-3

Direct methods have been developed to access the title nucleoside 1 from 2'-deoxyuridine (dU). The C-4 pentafluorophenyl group of 1 is readily displaced by amine nucleophiles forming N-4 substituted cytosines in good to excellent yields.