Tetrahedron Asymmetry p. 1525 - 1533 (1994)
Update date:2022-08-17
Topics:
Kardos
Genet
The total enantioselective synthesis of (-)-chanoclavine I 2 in twelve steps from indole-4-carboxaldehyde 4 is described. The key-step 3 → 6 which involves the formation of the C ring by creation of the C5-C10 bond is catalyzed by a chiral palladium (0) complex. The chiral ergoline synthon 6 is produced with an excellent diastereo- and enantioselectivity (up to 95% ee).
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Doi:10.1039/P29830001687
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