Tetrahedron Letters p. 3897 - 3900 (1994)
Update date:2022-08-29
Topics:
Lenz, Rainer
Zenk, Meinhart H.
A highly substrate specific enzyme has been discovered and purified to homogeneity, which transfers the acetyl-moiety from acetyl-coenzyme A to the 7-OH group of salutaridinol. The formed 7-O-acetyl-salutaridinol spontaneously closes the oxide bridge at pH 8-9 by allylic elimination furnishing the morphine precursor thebaine.
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