Oxytocin with N5,N5-dimethylglutamine and N4,N4-dimethylasparagine in the 4 and 5 positions: synthesis, pharmacological properties and mass spectral analysis

DOI: 10.1016/0223-5234(87)90035-3

Source and publish data:

European Journal of Medicinal Chemistry p. 453 - 456 (1987)

Update date:2022-08-16

Topics:

Authors:

Theodoropoulos, Dimitrios

Cordopatis, Paul

Dalietos, Demetrios

Furst, Arthur

Lee, Terry D.

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Article abstract of DOI:10.1016/0223-5234(87)90035-3

The analog of oxytocin <4-(N⁵,N⁵-dimethylglutamine), 5-(N⁴,N⁴-dimethylasparagine)>-oxytocin was synthesized and its structure was fully characterized by liquid secondary mass ion spectroscopy.The analog was found to be almost inactive in the uterotonic, anti-diuretic, pressor and milk ejection assays.Keywords: oxytocin / analog / synthesis / pharmacology / mass spectral analysis

Full text of DOI:10.1016/0223-5234(87)90035-3

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