CHIRAL SYNTHESIS OF (R)-(-)-MELLEIN AND (3R,4aS)-(+)-RAMULOSIN

Article abstract of DOI:10.1016/S0040-4020(01)96780-8

By employing an intramolecular Diels-Alder reaction as the key-step, (R)-(-)-mellein 1a (a metabolite of Aspergillus melleus) and (3R,4aS)-(+)-ramulosin 2 (a metabolite of Pestalotia ramulosa) were synthesised from ethyl(R)-3-hydroxybutanoate 3a.