Synthesis of 2-methyl-2-[[(7-methyl-7H-benzo[c]carbazol-10-yl) [14C]methyl]amino]. 1,3-propanediol mesylate. A potential antitumor agent

Article abstract of DOI:10.1002/jlcr.2580340803

2-Methyl-2-[[(7-methyl-7H-benzo[c]carbazol-yl)methyl]amino]-l,3-propanediol (1, 7U85) was synthesized as the mesylate salt in the [¹⁴C]-labelled form with specific activity 48.4 mCi/mmol suitable for metabolism and tissue distribution studies in animals. The synthetic sequence involved the regiospecific synthesis of a bromobenzo[c]carbazole by a modified Fischer indole synthesis, formylation by a Bouveault reaction, and reductive amination. The radiochemical purity was >97.3%.