Erratum to Salarin C, a new cytoxic sponge-derived nitrogenous macrolide [Tetrahedron Lett. 49 (2008) 4355] (DOI:10.1016/j.tetlet.2008.05.038)

Full text of DOI:10.1016/j.tetlet.2008.07.002

Tetrahedron Letters 49 (2008) 5437
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Tetrahedron Letters
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Erratum
Erratum to ‘‘Salarin C, a new cytoxic sponge-derived nitrogenous macrolide”
[Tetrahedron Lett. 49 (2008) 4355]
Ashgan Bishara a, Amira Rudi a, Maurice Aknin c, Drorit Neumann b, Nathalie Ben-Califa b, Yoel Kashman a,
*
a School of Chemistry, Tel Aviv University, Ramat Aviv 69978, Israel
b Department of Cell and Developmental Biology, Tel Aviv University, Ramat Aviv 69978, Israel
c Laboratoire de Chimie des Substances Naturelles et des Aliments, Faculté des Sciences et Technologies, Université de la Réunion, 15 Avenue René Cassin, B.P. 7151,
97715 Saint Denis, Cedex 9, France
The editors and publishers regret that in the above Letter concentrations of the active compounds were erroneously given in millimolars
(mM) rather than in micromolars (lM) and in mg/ml rather than in lg/ml. The penultimate sentence of the Abstract and the passage ‘The
anti-proliferative activity of salarin C was dose-dependent. . . (e.g., geldanamycin)19’ on p 4357 are corrected as follows:
‘Salarin C was found to inhibit cell proliferation of human leukeamic cell lines UT-7 and K562 and the murine pro-B cell line Ba/F3 at
concentrations of 0.0005–0.5 lg/ml’.
‘The anti-proliferative activity of salarin C was dose-dependent; salarin C at concentrations of 0.0005–0.5 lg/ml was added to the cells
for 24 h, and cell viability was determined by MTT assay.18 Salarin C was by far more potent than salarins A and B, and tulearin A, ꢀ50%
inhibition of cell proliferation was obtained at 0.5
l
g/ml (1
l
M) of salarin C for the UT-7 cell line and at 0.05
l
g/ml (0.1
M of salarin C. The effec-
M) is comparable, and even lower than those of other chemotherapeutic agents (e.g.,
lM) for the K562
cell line. The sensitivity of the Ba/F3 cells was much higher as their proliferation was arrested completely at 0.1
tive concentration range of salarin C (IC50 0.1–1
geldanamycin).19
l
l
’
DOI of original article: 10.1016/j.tetlet.2008.05.038
* Corresponding author. Tel.: +972 36408595; fax: +972 36409293.
E-mail address: kashman@post.tau.ac.il (Y. Kashman).
0040-4039/$ - see front matter Ó 2008 Elsevier Ltd. All rights reserved.
doi:10.1016/j.tetlet.2008.07.002