A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides

DOI: 10.1016/S0040-4039(98)02594-5

Source and publish data:

Tetrahedron Letters p. 1109 - 1112 (1999)

Update date:2022-09-26

Topics:

Authors:

Faul, Margaret M.

Winneroski, Leonard L.

Krumrich, Christine A.

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Article abstract of DOI:10.1016/S0040-4039(98)02594-5

Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. The mechanism of the reaction is discussed.

Full text of DOI:10.1016/S0040-4039(98)02594-5

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