Synthesis and antitumor activity of novel nitrogen mustard derivatives of 2, 4, 6-trioxo-1, 3, 5, 2-triazaphosphorine

Article abstract of DOI:10.1080/10426500008076328

A series of novel nitrogen mustard derivatives of 2, 4, 6-trioxo-1, 3, 5, 2-triazaphosphorine have been synthesized by the cyclization reactions of N, N-bis(2-chloroethyl)amino phosphonyl diisocyanate with amines. The structures of the products were confirmed by ¹H NMR, IR, MS and elemental analysis. The preliminary bioassay indicated that some of the compounds significantly inhibited the growth of Leukemia L1210 cell in vitro.

Full text of DOI:10.1080/10426500008076328

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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Synthesis and Antitumor
Activity Of Novel Nitrogen
Mustard Derivatives Of
2, 4, 6-Trioxo-1,3,5,2-
Triazaphosphorine
Shui-Ming Lu a , Li-Juan Mao b & Ye-Rong Xiong a
a Department of Chemistry , Central China
Normal University , Wuhan, 430079, P. R. China ,
Hubei
b Institute of Elemento-Organic Chemistry ,
Nankai University , Tianjin, 300071, P.R. China
Published online: 19 Dec 2006.
To cite this article: Shui-Ming Lu , Li-Juan Mao & Ye-Rong Xiong (2000) Synthesis
and Antitumor Activity Of Novel Nitrogen Mustard Derivatives Of 2, 4, 6-
Trioxo-1,3,5,2-Triazaphosphorine, Phosphorus, Sulfur, and Silicon and the Related
Elements, 165:1, 91-97, DOI: 10.1080/10426500008076328
To link to this article: http://dx.doi.org/10.1080/10426500008076328
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