Synthetic approaches to macromolecular models for ion channel proteins

Article abstract of DOI:10.1016/S0040-4039(98)01313-6

The synthesis of a branched peptide is described using a ligation strategy to couple two peptides one of which is fully deprotected while the other is in a protected form. The ligation step involves formation of a thioether bond by using the thiol of a cysteine on the deprotected sequence to displace bromide from a bromoacetyl moiety on the second peptide.