The synthesis of [3H]KW-2189, a novel active antitumor antibiotic

DOI: 10.1002/(SICI)1099-1344(199706)39:6<471::AID-JLCR991>3.0.CO;2-K

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 471 - 477 (1997)

Update date:2022-08-29

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Authors:

Nagamura, Satoru

Kinugawa, Masahiko

Ogasa, Takehiro

Saito, Hiromitsu

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Article abstract of DOI:10.1002/(SICI)1099-1344(199706)39:6<471::AID-JLCR991>3.0.CO;2-K

The synthesis of [³H]KW-2189, 2, a novel active antitumor antibiotic, is described. The key intermediate 6 in the synthesis, was synthesized in four steps from duocarmycin B2 (1). Treatment of 6 with [³H]methyl iodide in the presence

Full text of DOI:10.1002/(SICI)1099-1344(199706)39:6<471::AID-JLCR991>3.0.CO;2-K

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