Journal of Medicinal Chemistry p. 4450 - 4454 (1992)
Update date:2022-08-29
Topics:
Taylor, Edward C.
Kuhnt, Dietmar
Shih, Chuan
Rinzel, Sharon M.
Grindey, Gerald B.
et al.
N-<4-<2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid (15), prepared in five steps from 2-pivaloyl-7-deazaguanine, has been found to be an antitumor agent with its primary site of action at thymidylate synthase
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