A Dideazatetrahydrofolate Analogue Lacking a Chiral Center at C-6, N-pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic Acid, Is an Inhibitor of Thymidylate Synthase

Article abstract of DOI:10.1021/jm00101a023

N-<4-<2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid (15), prepared in five steps from 2-pivaloyl-7-deazaguanine, has been found to be an antitumor agent with its primary site of action at thymidylate synthase